266 papers
This study reveals that while the inherent chirality driven by Myo1D causes a variable left-right twisting bias during *Drosophila* germ band extension, this instability is counteracted and corrected by Scab integrin-mediated friction between the embryo and the eggshell, ensuring the morphogenetic process remains invariant.
This study establishes a reproducible fetal lamb model of complex gastroschisis that demonstrates the condition's increasing prevalence and associated structural and functional bowel deterioration over time, offering a valuable tool for understanding disease progression and morbidity.
EpiCure is a versatile, user-friendly software tool designed to accelerate and streamline the manual curation of segmentation and tracking errors in large-scale epithelial tissue microscopy movies, thereby ensuring accurate single-cell dynamics analysis for developmental and stem cell research.
By analyzing Hurst exponent dynamics across two large developmental datasets, this study reveals a cascading pattern of neural plasticity in language-related brain regions, where earlier maturation in posterior and thalamic areas underlies early sensitive periods, while slower cortical increases in skilled children and plateauing around age nine suggest a neural basis for protracted plasticity and subsequent declines in syntax learning.
This study reveals that spermatogenesis involves a stage-specific metabolic rewiring where early prophase cells prioritize de novo nucleotide synthesis via glutamine and fatty acid oxidation to build a reserve, while late prophase cells suppress biosynthesis and rely on these pre-synthesized pools to fuel a surge in RNA production.
This study demonstrates that aging impairs zebrafish caudal fin regeneration by disrupting regenerative gene networks and causing mitochondrial dysfunction, which collectively compromises the bioenergetic capacity required for tissue repair.
This study reveals that the epigenetic regulators MLL3/4 govern the differentiation of pluripotent stem cells by activating cellular respiration through the upregulation of the glycolytic enzyme HK2 and the mitochondrial OGDH complex.
This study presents a high-resolution proteomic atlas of zebrafish embryonic development across 16 time points, revealing distinct protein expression clusters, identifying chromosome 4-localized zinc finger transcription factors active during zygotic genome activation, and highlighting significant discordance between transcript and protein dynamics while confirming temporal stability for fundamental biological processes.
This study demonstrates that heparan sulfate is essential for the regulated export of the Drosophila FGF ortholog Branchless to the cell surface and for the subsequent non-autonomous activity of receiving cells' cytonemes.
This study reveals that mitochondrial state in embryonic angiogenic tip cells, regulated by the microRNA-125a-PGC1a axis, instructively encodes the topology of protective brain collateral networks, thereby determining lifelong cerebrovascular resilience.
This study demonstrates that FGF/MAPK pathway overactivation at the ciliary base drives reduced neurogenesis and impaired Purkinje cell formation in Joubert syndrome cerebellar organoids, a defect that can be rescued by pharmacological inhibition of FGF receptors.
This study reveals that TET1's non-catalytic activity, rather than its enzymatic function, is essential for maintaining H3K4me3 levels in prospermatogonia to prevent aberrant de novo DNA methylation and ensure proper sperm hypomethylation in the male germline.
By leveraging natural variation in transplacental transfer efficiency and utilizing isoform-resolved placental transcriptomics, this study reveals that perinatal outcomes like birth weight and gestational age are driven by distinct co-expression network architectures rather than simple gene expression changes, with birth weight specifically showing a dose-dependent increase in network centrality and compartmentalization that is masked by traditional gene-level aggregation.
This study reveals that innate immune activation in *Drosophila* hemocytes is driven by a conserved metabolic reprogramming toward enhanced mitochondrial oxidative phosphorylation, which relies on Drp1-mediated mitochondrial fission and specific carbon sources to support effective immune responses.
Chronic morphine exposure disrupts embryonic development and epigenetic memory by repressing the chromatin regulator Smchd1, which leads to the failure of X-chromosome inactivation and genomic imprinting through altered DNA methylation and histone modifications.
This study reveals that while individual disruptions of the RNA-binding proteins POS-1 or GLD-1 binding to the *glp-1* 3'UTR have minimal effects, the simultaneous elimination of both binding sites significantly impairs reproductive fecundity by disrupting the robust post-transcriptional regulation required for optimal germline proliferation and embryogenesis.
This study reveals that Drosophila Tau maintains epithelial morphogenesis and Notch signaling homeostasis in Malpighian tubules by coordinating vesicular trafficking and endocytic processes, the disruption of which leads to tissue hyperplasia and impaired receptor activation.
By comparing early mouse and human forebrains using single-cell transcriptomics and 3D spatial imaging, this study reveals that human-specific telencephalic patterning initiates as early as the fourth post-conception week through delayed ventral SHH signaling and an anterior FGF signature, which collectively drive distinct progenitor identity allocation and reduced diversity compared to mice.
This study reveals that the male bias in medulloblastoma is primarily driven by prenatal developmental factors and the presence of male gonadal hormones, specifically testosterone, which increase the abundance and proliferation of cerebellar progenitors susceptible to tumor formation.
This study constructs a single-cell atlas of postnatal human lung development to identify temporally regulated gene expression patterns, revealing that genetic susceptibility to chronic lung diseases like COPD is linked to specific windows of vulnerability during early postnatal vascular maturation.